Association of hyper IgE with herpetic viral encephalitis and ecthyma gangrenosum in a male Egyptian patient

نویسندگان

چکیده

Abstract There are two forms of hyper-immunoglobulin E syndromes (HIES): a dominant form (AD-HIES) is caused by mutations in signal transducer and activator transcription 3 (STAT3), recessive (AR-HIES) dedicator cytokinesis 8 (DOCK8). DOCK8 autosomal hyper IgE syndrome patients have more symptomatic neurologic disease than those with STAT3 deficiency. Involvement the central nervous system HIES has been rarely reported. Being rare primary immuno-deficiency, may be underdiagnosed under-reported. In abnormalities definite manifestations, very few articles were published previously which vary from hemiplegia to partial facial nerve paralysis children acute disseminated encephalomyelitis (ADEM), but viral encephalitis not Herein, we describe 21-year-old male presented fever, pneumonia, skin abscesses, altered consciousness who proved herpetic encephalitis. The purpose this study emphasize that complications occur syndrome. case series, no cases described encephalitis, best our knowledge, first description herpes simplex patient

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ژورنال

عنوان ژورنال: The Egyptian Journal of Internal Medicine

سال: 2023

ISSN: ['1110-7782', '2090-9098']

DOI: https://doi.org/10.1186/s43162-022-00186-w